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What are the early symptoms of FIP in cats?

Strictly speaking, it is difficult to diagnose feline infectious peritonitis (FIP) before an autopsy. So far, there are no specific clinical pathological signs or indications for laboratory tests. In layman’s terms, only when a cat undergoes an anatomical examination after death, can one determine the cat. Whether you are actually infected with infectious peritonitis, all cases are suspected while alive. Some people will say that there are cat coronavirus test strips in many hospitals. In fact, there is no separate test paper for FIP transmission. The so-called test for FIP transmission is only to check whether the cat carries coronavirus in the cat, and the non-mutated coronavirus will not cause cats. After abdomen, the complete diagnosis is only waiting for an autopsy. But we can still anticipate the danger coming from some clues of cat life. If your cat is young / young (0-5 years old) and has repeated fever for more than two consecutive days (body temperature> 39.2 ° C, it gradually decreases at night after dusk), loss of appetite or intermittent anorexia, mental depression and accompanying Symptoms of dyspnea, eye lesions, and increased abdominal circumference. There are recent possible events that cause cat stress (changes in family members, changes in cat’s living environment due to fostering / moving / home layout changes, bathing, going out, etc.), I suggest taking the master to a reliable hospital for testing immediately to rule out the possibility of abdominal transmission or timely treatment.

Mao Junfu and others retrospectively counted 146 suspected FIP infection cases during a 2018 in a chain animal hospital in Beijing. Clinical findings found that young cats younger than 2 years old are relatively susceptible to FIP, and the incidence of repeated fever and loss of appetite is 60% The incidence of chest / ascites (dyspnea / increased abdominal circumference) was 65% and almost all were accompanied by fever symptoms, and the incidence of eye lesions was 11%. Tang Xiaojuan and others believe that cats under 5 years old are susceptible to cat infectious peritonitis virus, which is related to low resistance of young cat.

FIP is divided into dry (exudative) and wet (non-exudative). Symptoms are often not obvious at the early stage of the onset, but the sooner the cat plague is saved, the higher the survival rate. The shit officials must be familiar with the normal pace of life of the cat and pay close attention to the status of the cat in order to discover abnormal conditions in time. It is also the duty of the owner to be familiar with the habits of the pet.

Early stage: loss of appetite or intermittent anorexia, lack of energy, poor physical fitness, weight loss.

Shovel officers must pay attention to the daily life rules of cats, when to play and rest, how much food to eat and how much water to change how weight changes … It is best to track records and form a paper / electronic version of the cat feeding log to facilitate timely discovery Sensitive changes in cat ’s appetite and rest. If your cat loses interest in the foods he usually eats, the amount of meals drops significantly, and he is even less interested in cat snacks and canned food. At the beginning, although FPV is necessary for families with many cats, it is necessary to say that the cat FIP ​​virus can be transmitted through the feces. Therefore, sharing the litter box will increase the risk of FIP infection between cats. Multi-cat environment has always been considered FIP The main risk factors [4]. When there are multiple cats in the family at the same time, be sure to track the situation of each cat, if there are abnormalities in individual cats, more attention should be paid. Cats with unhealthy bodies tend to be insane, usually manifested as drowsiness and poor physical performance. A normal cat sleeps 12-18 hours a day, but it is not continuous and tends to fall asleep at multiple points in multiple positions. If the cat maintains an uncomfortable posture in a fixed position (such as sitting in a curled up), after a long period of continuous sleep and only necessary activities such as diet and excretion / legacy after getting up, the action is weak, for the usual love to play Toys and interactions with the owner lose interest, most of them are sick.

Mid-term: body temperature rises above 39.2 ° C (high at dusk and slowly decreases at night), urine color turns yellow, vomiting and diarrhea.

Always have a thermometer for cats at home. If your cat shows one or more of the pre-symptoms described above, check the temperature in a timely manner and multiple times. Cat body temperature is higher than that of humans. Cat fever is classified as body temperature> 39.2 ° C. In hospitals, to exclude stress-induced body temperature increases, 39.5 ° C is occasionally selected as the critical value to assess fever. A certain percentage of FIP cats have symptoms of jaundice, but no research has shown its mechanism. Related conjectures include hemolytic jaundice, biliary metabolism and excretion of vasculitis in the liver, and granuloma deposition in the liver. At this time, the cat urine will occasionally turn yellow, and it may be brown or even soybean oil. Tracking the color changes of cat litter balls also helps to intervene in medical treatment in the early stages of the disease.

At this stage, due to the effect of the virus, the number of white blood cells in the cat’s body decreased sharply, the cat’s resistance suddenly dropped, and a variety of secondary infections were complicated. Digestive system problems are manifested in a few cases of FIP, and vomiting and diarrhea and watery / bloody diarrhea are more common. At this time, it is often a period of accelerated disease, which must be paid attention to. In addition, clean cats tend to hide diarrhea and vomit in horny places (under the bed, cracks and even under the carpet). Be sure to pay attention when cleaning up the house

Later clinical symptoms vary depending on the type.

Wet FIP (exudative infectious peritonitis) is relatively common, accounting for approximately 60% to 70% of all cases [7], and the epidemic develops rapidly and is easily detected. Wet FIP is characterized by fibrous pleurisy and peritonitis, accompanied by obvious pleural, abdominal, and pericardial effusions, which severely hinder breathing. The effusion is not the product of the virus peritonitis virus, but a manifestation of the overreaction of the humoral immune system. The pleural effusion forces the respiratory organs, causing the sick cat to have difficulty in breathing and may show symptoms of anemia. The abdomen will gradually increase fluid accumulation, causing the abdomen to swell and gradually exceed the normal body width. You can feel the water fluctuations when you feel Accompanied by the sound of water. The course of disease varies from days to weeks, and some cats die quickly.

Dry FIP (non-exudative infectious peritonitis) has a long course and can last for weeks or even 4 months. It mainly invades tissues and organs such as eyes, central nerves, kidneys and liver, and is almost not accompanied by ascites. In order to isolate the parts of the body tissue that have been invaded by the peritonitis virus, the immune system of the sick cat generates granulation tissue to wrap and block these parts. Because the peritonitis virus may invade various tissues and systems such as the eyes, liver, kidneys, lymph nodes, nervous system, etc., the immune system will react excessively in these parts, causing pus granuloma lesions in different organs, presenting various symptoms, but killing the cat. . · Eye infections show corneal edema and deposits, turbid eyes, inflammation of the ciliary body, purulent redness of the atrial fluid, fibrin clots in the anterior chamber of the eye, and flaming retinal bleeding in the early stages of the disease.

· When the central nervous system is damaged, it manifests as ataxia, cramps and convulsions.

· Jaundice may occur when the liver is damaged. See mid-term symptoms.

· The kidney is invaded, and sick cats often have symptoms such as hematuria and renal failure. ‍

With prevention as the mainstay, there are medicines that can cure infectious peritonitis is no longer incurable with the emergence of medicines such as GC376 and GS44152, which inhibit the replication of feline coronavirus. Studies have shown that these drugs are safe and effective, but because of the instability of the drugs, the high cost of the economy, and the low clinical data, different scholars hold different opinions. It is far more active to prevent FIP from happening through scientific and reasonable means than to cure them. No one wants to see his master suffer. Number and cleanliness of cat litter pots: Because cat coronavirus can be spread through feces, cat litter pots should be kept away from cat food bowls as much as possible. The number of cat litter pots is determined by the N + 1 principle, where N is the number of cats. It is necessary for the shit shovel officer to clean the litter box daily. When changing the whole litter box, use 1:32 times the bleach / bleach product of the same series, including calcium hypochlorite and sodium dichloroisocyanurate or use Wash with hot soapy water. The open and ventilated litter box is difficult to gather the smell, but it is not conducive to the accumulation of pathogens. The top-entry litter box can greatly reduce the possibility of cat litter splashing outside.

For multi-cat families, ensure that the number of cats in each area does not exceed 3, to avoid the possibility of mutual infection, try to keep the cats in the house, try to minimize the change in the layout of the items in the house, or move the house. Sufficient time to adapt. Clean the cat’s living environment regularly with a non-pungent disinfectant, recommended once a week. Those with conditions can purchase ultraviolet lamps to irradiate human and cat living environment and common items twice a week. Note that people and cats should not be exposed to ultraviolet light. When the ultraviolet light is turned on, the irradiation environment should be closed and away from animals.